A BIO 123Z General Biology II Lab (1)
Second course in a two-semester lab sequence which explores fundamental concepts in biology and introduces common biology laboratory techniques. Emphasis is placed on experimental design, interpretation of results and critical composition of lab reports. Topics covered include Biochemistry and Molecular Biology, Laboratory Math, Genetics, Cell Biology, Neurobiology and Behavior. One laboratory period per week. May not be taken by students with credit for A BIO 111. Prerequisite(s) or corequisite(s): A BIO 121. Offered spring semester only.

T BIO 176 Genomics & Biotechnology: The Broad Ranging Impact on Mankind (3)
The sequencing of the genomes of a large number of organisms, from bacteria to human, has provided enormous insights into a wide range of human endeavors.  Almost no aspect of human knowledge has been untouched by the information being compiled. The information gathered has also driven the development of new technologies designed to explore and exploit the information gathered. The goal of this course will be to familiarize students with the nature of the information that can be gathered from genomics and the benefits derived from the new biotechnologies. Also, simple research problems will be assigned to introduce students to the web based resources and programs used to analyze genomic data. Open to Honors College students only.

A BIO 199 Contemporary Issues in Biological Sciences (1—3)
Issues from the current literature in selected areas of biological sciences. Particular areas of study to be announced each semester. Intended for students interested in exploring in depth themes covered in large lecture classes. May be repeated for credit when topic varies. Prerequisite(s): consult instructor for specific prerequisites. S/U or A-E graded.

A BIO 205 Human Genetics (3)
Survey of human genetics emphasizing the principles and mechanisms of inheritance and including the analysis of the genetic material of humans; the behavior of genes in individuals families, and populations; and the implications for human behavior and evolution, medicine, and society. Does not yield credit toward the major in biology. Prerequisite(s): A BIO 110 or 120, and 111 or 121, or permission of instructor.

A BIO 209 The Human Organism (3)
An introduction to the human organism focusing on evolution, development and behavior, and emphasizing applications and implications for modern life and human society. Yields credit toward the major in human biology but not towards the major in biology. May not be offered in 2009-2010.

A BIO 212Y Introductory Genetics (4)
Genetics from the classical Mendelian Laws of inheritance to molecular genetics. Topics will include: DNA structure and replication; Mendelian genetics and recombination; population, fungal, somatic cell, and bacterial genetics; gene organization; the genetic code; mechanisms of gene expression and regulation; and applications of genetic technology. Three class periods and one discussion section. Prerequisite(s): A BIO 110 or 120, and a grade of C (2.0) or better in A BIO 111 or 121.

A BIO 216 Perspectives in Life Sciences (3)
Advancements in biological sciences necessitate decisions about how to use new information, techniques, and technology. This course examines the impact of specific innovations on society, health care, and the environment. The effects of public perception on implementation of scientific discoveries will be considered. Prerequisite(s): A BIO 110 or 120, and A BIO 111 or 121. May not be offered in 2009-2010.

A BIO 217 Cell Biology (3)
An introduction to modern cell biology. This course will present the basic organization of eukaryotic cells while stressing their elaborate structural-functional integration. The cells fundamental properties conserved through evolution will be stressed. Prerequisite(s): A BIO 212Y.

A BIO 218 Introduction to Plant Biology (3)
An introduction to the great group of organisms that form the basis of our food web and provide us with our oxygen. Topics will include plant origins and evolution, physiology, morphology, and development. Along the way we will consider more general principles of body design and pattern formation, the unfolding of complex form from relatively unstructured beginnings. Prerequisite(s): A BIO 110 or 120 and 122, and A BIO 111 or 121 and 123Z, or equivalent, or permission of instructor.

A BIO 219 (= A CHM 219) Viruses and Human Society (3)  
This interdisciplinary course will focus on viruses and their impact on human society. It will offer a multi-faceted examination of viruses such as Ebola, SARS, West Nile, HPV and HIV, not only as microbes and pathogens, but also as vehicles for the transport of genetic materials, as evolving populations of individuals, as self-assembled nanoscale supramolecular aggregates, and as self-replicating packages of control logic. This will be followed by a wide range of case studies, each of which will connect one virus to some of the complex, capacious and evolving public issues associated with the political, economic, religious, feminist, agricultural, medical, pharmaceutical, and socio-economic implications of its spread. Finally, one virus and the disease it causes, HIV/AIDS, will be used to provide an in-depth example of the evolution of a viral pandemic, from the molecular to the international stage, and the impact of culture, integration and limited international resource allocation on its global ascendance. For the benefit of chemistry majors taking the course, biological concepts germane to the subject matter will be covered. Only one version of A BIO 219 may be taken for credit. Prerequisite(s): A BIO 111, or 121 & 123, and A CHM 121. May not be offered in 2009-2010.

A BIO 222 Biological Consequences of Global Climate Change (2)
Introduction to the background, predictions, and empirical evidence for biological effects of increases in atmospheric greenhouse gases. Emphasis on regional-scale consequences for terrestrial and aquatic ecosystems, including agricultural and urban ecosystems. Lectures, demonstrations, exercises, and discussions based on current science, with focus on NE North America. Prerequisite(s): A BIO 110 or A BIO 120 and 122 or equivalent.   

A BIO 230 People and Resources in Ecological Perspective (3)
Introduction to people as biological and cultural organisms and to ecological resources and services (e.g. energy flow and productivity, matter cycling, succession in ecosystems, use of resources, biodiversity). Concepts and connections to major issues of sustainability such as food and energy production, exploitation of resources (e.g. fresh water, oil, soil), pollution, global warming and associated climate changes, human overpopulation, public health and social problems all considered in a historical and contemporary context. Does not yield credit for the major in biology. Prerequisite(s): sophomore standing or above.

A BIO 298 Contemporary Issues in Biological Sciences, with Laboratory  (1-3)
Laboratory classroom training in selected areas of biological sciences. Particular areas of study to be announced each semester. Yields laboratory credit towards the major in biological sciences. May be repeated for credit when topic varies. Prerequisite(s): consult with instructor for specific prerequisites. S/U or A-E graded. May not be offered 2009-2010.

A BIO 302Z Cell Biology Laboratory (2)
Introduction to modern techniques in cell biology, including advanced optical microscopy, DNA extraction and analysis, protein electrophoresis and western blotting, cell homogenization and fractionation, and cell culture. These techniques are used to investigate cell motility, membrane structure and permeability, mitochondrial respiration, DNA replication, the cell cycle, and cell adhesion. One laboratory period per week; additional time as required. Prerequisite(s) or corequisite(s): A BIO 217 and 365.

A BIO 303 Developmental Biology (3)
The development of form and function in animals with emphasis on molecular analyses of organismal and cellular events underlying fertilization, early development, morphogenesis and growth. Prerequisite(s): A BIO 212Y.

A BIO 305 Developmental Biology Laboratory (2)
This laboratory course examines the mechanisms of animal and plant development at the molecular and cellular level by modern and classical techniques. Topics include gametogenesis, fertilization, early and later development, cell division and morphogenesis. One laboratory period per week; additional time as required. Prerequisite(s) or corequisite(s): A BIO 303.

A BIO 307 (= A ANT 317) Exercise Physiology (3)
This course will provide a broad introduction to the field of exercise physiology. Topics covered will include cellular energy metabolism, pulmonary and cardiovascular responses to exercise, muscle physiology, training, nutrition, body composition, and exercise testing. Students will spend some time in the human performance laboratory where the focus will on be applied exercise physiology and performance testing. Specialized topics include exercise at high altitude, temperature regulation, sports nutrition, exercise performance during the growth and development period, and the relationship of exercise and physical activity to human health and disease. Only one version of A BIO 307 may be taken for credit. Prerequisite(s): A BIO 110 or 120 and A BIO 111 or 121. May not be offered in 2009-2010.

A BIO 308 Parasitic Diseases and Human Welfare (3)
Ecological, medical, and social interrelationships of selected parasitic diseases of people and domestic animals in temperate, semi-tropical, and tropical climates; role of wild animals as reservoirs or vectors of parasitic diseases in humans. Prerequisite(s): 10 credits of biology or permission of instructor.

A BIO 314 Microbiology (3)
Introduction to the morphology, physiology, structure, genetics, and metabolism of microorganisms, including the roles played by microorganisms in medical, environmental, agricultural, and biotechnological sciences. Prerequisite(s): A BIO 212Y and 365.

A BIO 315 Microbiology Laboratory (2)
Laboratory studies that deal with the culture and study of microorganisms, the dynamics of microbial growth, and the physiological basis of bacterial identification. One laboratory per week; additional flexible time as required. Prerequisite(s): A BIO 212Y and 365. Prerequisite(s) or corequisite(s): A BIO 314.

A BIO 316 Biogeography (3)  
Evolutionary ecology of geographic dispersal and range size; ecological niches and local abundance; allometry and population density; speciation and extinction; invasive species; island biogeography, metapopulations; ecological communities under climate change. Prerequisite(s): 15 credit hours in biology; A MAT 106 or A PHY 140. May not be offered in 2009-2010.

A BIO 317 Comparative Animal Physiology (3)
The physiological mechanisms employed by animals in meeting the stresses imposed by different environments. Considers strategies of adaptive radiation including toleration, avoidance, and regulation from an evolutionary perspective. Prerequisite(s): A BIO 110 or 120 and A BIO 111 or 121 and junior status. May not be offered in 2009-2010.

A BIO 318 (= A ANT 312; formerly A BIO 419/A ANT 412) Human Population Genetics (3)
Population genetics theory is the foundation of evolutionary biology and contributes heavily to modern ideas in ecology, systematics, and agriculture. This course is an introduction to that theory with special emphasis on evolution. Only one of A ANT 312 and A BIO 318 may be taken for credit. Prerequisite(s): A ANT 211 or A BIO 205 or 212Y. May not be offered in 2009-2010.

A BIO 320 Ecology (3)
Natural selection as an organizing principle; single-species population dynamics, geometric-mean growth, density-dependence, chaos in ecology; age structure, selection on life-histories, population projection; models for competition, predation, epidemics, and mutualism; species diversity, abundance models during community development. Prerequisite(s): A MAT 106 or A PHY 140, A BIO 212Y.

A BIO 321 The Insects (3)
A multilevel examination of the biology of insects, with particular emphasis on those aspects of design, physiology and behavior that make them so distinctive and successful. Prerequisite(s): A BIO 110 or A BIO 120 and 122, and A BIO 111 or 121 and 123Z, or equivalent.

A BIO 325 Comparative Anatomy of Chordates (4)
Comparative study of embryonic development, functional morphology, adaptive radiation, and evolution of chordates. Three class periods, one laboratory period each week. Not open to freshmen. Prerequisite(s): 12 credits of biology or permission of instructor.

A BIO 326 Environmental Microbiology Laboratory (2) 
Explores the role of microbes in natural and human-impacted systems through topics such as nutrient cycling, waste degradation, bioremediation, waterborne disease, food safety, and pollution control. Informal lectures and current events discussions may be incorporated into laboratory exercises. One laboratory per week; additional flexible time as required. Prerequisite(s): A BIO 212Y, and 314. Prerequisite(s) or corequisite(s): A BIO 365.
 
A BIO 327 (formerly A BIO 445) Experimental Ecology (3)
Fundamental ecological concepts are demonstrated with experimental manipulations and comparative assessment techniques. Local ecosystems are studies; the focus is on the effects of land use on ecosystem structure and function. Ecological assessment skills are developed in the field and laboratory. Lectures couple fundamental and applied topics, balancing understanding of ecological principles with realistic environmental problem solving. Students contribute to a report that becomes part of the record for a municipal wetland. Prerequisite(s): A BIO 110 or A BIO 120 or permission of instructor. May not be offered in 2009-2010.

A BIO 329 Genetics of Human Disease (3)
Four categories of the involvement of human genes in disease will be explored using specific examples to illustrate general phenomena. First, inheritance of diseases caused by single mutant alleles will be discussed. Second, the pre-disposition of specific genotypes to disease will be investigated highlighting the interplay between genes and between the genes and the environment. Third, genetic instabilities that give rise to genetic rearrangements and chromosome loss will be explored. Fourth, the genetic interplay between host and pathogen will be explored with respect to the evolution of protective mechanisms by the host and evasion by the pathogen, and how new pathogens emerge. For each category, multiple cases of specific diseases will be discussed with an emphasis on both the molecular basis of the genetic interactions and the population genetics of disease spread and persistence. The potential of modern genetic techniques to provide diagnosis and treatment of diseases will also be discussed. Prerequisite(s): A BIO 212Y.

A BIO 335 Immunology (3)
The structure and function of the antibody molecule and of reactions between antigen and antibody. Also covers cellular interactions in the immune response as well as both the beneficial and harmful consequences of the response. Prerequisite(s): A BIO 212Y. Prerequisite(s) or corequisite(s): A BIO 365.

A BIO 336Z Laboratory in Immunology (2)
Modern laboratory techniques will be performed to study the cellular and humoral components of the immune system; immune cells and cell markers, immunoglobulin purification and characterization, antibody and antigen identification assays including immunodiffusion and immunoelectrophoresis, and enzyme-based immunoassays (ELISA). One laboratory per week, plus additional flexible time as required. Prerequisite(s) or corequisite(s): A BIO 335.

A BIO 341 Neurobiology (3)
The structure and function of the nervous system examined at the cellular level. Topics include: organization of nervous systems; morphology and physiology of nerve cells; synaptic transmission; sensory processing; cellular circuitry underlying “simple” behaviors; cellular basis of learning; and the development of neuronal connections. Prerequisite(s): A BIO 111 or 121.

A BIO 342 Neurophysiology Laboratory (2)
A computer-based laboratory course examining the electrophysiological properties of the nervous system. The course will cover basic principles underlying resting potentials, passive electrical properties, action potentials, synaptic transmission and oscillatory neural networks. Simulation software will be used to model nerve cells and neural networks. Demonstrations of basic electrophysiological techniques will parallel the computer simulations. Prerequisite(s): A BIO 341 or permission of instructor.

A BIO 343 Evolutionary Biology and Human Health (3)    
This course illustrates the importance and utility of evolutionary perspectives on various topics related to human health. In addition to the "how" questions, this course also introduces the "why" questions. Various evolutionary hypotheses are examined. Arguments for and counter-arguments against each hypothesis are presented to foster understanding of each topic. Selected topics include infectious diseases, pathogen virulence, allergy/asthma, mental health/addiction, genetic disorders, diseases of civilization, sex, pregnancy, and aging. Prerequisite(s): a course in genetics.

A BIO 365 (= A CHM 342) Biological Chemistry I (3)
The chemistry and biochemical interrelationship of carbohydrates, lipids, and nucleic acids; enzyme catalysis and introduction to metabolism. Only one version of A BIO 365 may be taken for credit. Prerequisite(s): A CHM 220 and 221; and a grade of C (2.0) or better in A BIO 212Y.

A BIO 366 Biological Chemistry II (3)
Control and regulation of metabolic pathways, expression and transmission of genetic information, and a variety of selected current topics. Prerequisite(s): A BIO 365.

A BIO 367 Biochemistry Laboratory (2)
This laboratory course is designed to provide basic training in various procedures used in present day biochemical research. These will include methods for protein purification, enzyme kinetics, peptide sequencing, and fractionation of intracellular components. In addition, biochemical processes such as glucose metabolism and photosynthesis will be studied. One laboratory period each week. Prerequisite(s) or corequisite(s): A BIO 365 or equivalent and permission of instructor.

A BIO 389Z Writing in Biology (1)
Students who are concurrently registered in, or have previously taken, any 300 or 400 level biology course which yields credit toward the major, may with permission of the instructor of that course, enroll in A BIO 389Z and fulfill a writing intensive version of that other course. One additional meeting per week in which writing techniques and experiences are stressed is required. Written work that will be used for credit in A BIO 389Z must be in addition to any writings required for the companion course. Prerequisite(s) or corequisite(s): a companion biology course at the 300 or 400 level. S/U graded.

A BIO 397 Topics in Biology (1-3)
Issues from the current literature in selected areas of biology. Particular areas of study to be announced each semester. Yields credit toward the major in biological sciences. May be repeated for credit, when topic varies. Prerequisite(s): junior or senior standing, and permission of instructor. May not be offered 2009-2010.

A BIO 398 Topics in Biology, with Laboratory (1-3)
Issues in selected areas of biology. Particular areas of study to be announced each semester. Yields laboratory credit toward the major in biological sciences. May be repeated for credit, when topic varies. Prerequisite(s): junior or senior standing, and permission of instructor. May not be offered 2009-2010.

A BIO 399/399Z Supervised Research for Juniors (2—3)
Individual, independent research on selected topics in biology. Critical analysis of selected research papers. Junior majors in the department of biological sciences apply for this course through the prospective research adviser. Students taking two or more semesters of A BIO 399, 399Z, 499, or 499Z will prepare a poster or make an oral presentation at the Departmental Research Symposium. A copy of the final written report of each semester’s work, preferably typewritten in journal format, is kept on permanent file in the department. May be taken either semester. A maximum of 6 credits may be earned in A BIO 399 and 399Z.

A BIO 402 Evolution (3)
The patterns and processes of biological change with time from the origins of life, through major evolutionary innovations, to the development of human culture. Fundamental concepts in biology will be stressed, including information, mutation, selection, random drift, and adaptation. Prerequisite(s): A BIO 212Y.

A BIO 406 Vertebrate Histology (4)
Microanatomy and function of animal cells, tissues and major vertebrate organs, excluding the brain. Practical work with bright-field microscopy and preparation of formalin-fixed, paraffin-embedded, sectioned and stained tissues. Three class periods, one laboratory period each week. Extra time may be needed to complete individual projects. Prerequisite(s): A BIO 212Y; A BIO 325 and/or 410 recommended but not required.

A BIO 410 Human Physiology (3)
The functions of organ systems and their contributions to the functions of the human body as a whole. Topics to include: nervous, cardiovascular, respiratory, gastrointestinal systems and energy metabolism and temperature regulation. Two 1 1/2-hour lecture periods each week. Prerequisite(s): A BIO 110 or 120 and 122, A BIO 111 or 121 and 123Z, and A CHM 121 or 131.

A BIO 411Z Human Physiology Laboratory (2)
A mixture of lab experiments and computer simulations in systemic physiology with emphasis on membrane transport and excitability, muscle contraction, cardiovascular regulation, respiration and metabolism, acid-base control, renal system physiology, and sensory physiology. Three hours laboratory and one hour discussion per week, with emphasis on writing of scientific lab reports. Corequisite(s): A BIO 410.

A BIO 425 Molecular Biology (3)
Mechanisms of gene expression and regulation will be studied, using examples from bacteria and eukaryotes. Discussion will include experimental approaches to gene cloning and sequencing, analysis of DNA-protein interactions, and structure and function of RNA. Prerequisite(s): A BIO 212Y. Prerequisite(s) or corequisite(s): A BIO 365.

A BIO 426 Laboratory in Molecular Biology (2)
Experiments in the modern techniques of recombinant molecular biology will be performed. These may include restriction mapping of plasmids, gene cloning, DNA blotting, DNA sequence analysis, plasmid constructions, and gene expression studies. One laboratory per week, plus additional flexible time as required. Prerequisite(s): A BIO 212Y. Prerequisite(s) or corequisite(s): A BIO 365 and 425.

A BIO 432 Animal Behavior (3)
Evolutionary ecology of behavior, optimization, game theory; diet selection, foraging under uncertainty; group formation and dissolution; social parasitism, among-individual behavioral diversity; interaction with kin, conflict and cooperation; individual behavior and population dynamics. Completion of course requires submission of three papers. Prerequisite(s): 15 credit hours in biology and A MAT 106.

A BIO 435 Methods in Biotechnology (2)
This laboratory course is designed to provide training in modern techniques used in Forensic and Biomedical fields. These will include sequential methods for RT-PCR, PCR product cloning, analysis of recombinant plasmid clones, PCR-based VNTR genotyping, Restriction Fragment Length Polymorphism analysis, immunoblotting and immunofluorescence staining. One laboratory period each week. Prerequisite(s) or corequisite(s): A BIO 365 or permission of instructor.

A BIO 439 Ion Channels and Human Disease (3)
Ion channels are membrane proteins which transfer ions (e.g., Na+, K+, Ca2+, and Cl-) across to the cell membrane in response to physical or chemical stimuli such as change of membrane potential or ligand binding. They play important roles in excitable and non-excitable cells of many human tissues. Dysfunction of these membrane proteins is associated with various inherited and/or drug-induced human disorders. This course will introduce the structural and functional characterization of several families of ion channels and further discuss their physiological roles in several human tissues with an emphasis on cellular and molecular mechanisms why and how these channels are associated with human diseases. Students are required to read and learn from research literatures. Prerequisite(s): A BIO 217, and 341 or 410.

A BIO 441 Molecular Neurobiology (3)
The molecular biology of learning, memory, neural development and neurological disease. The course will relate the structure and function of receptors, second messangers, cytoskeletal proteins, transcription factors and gene structure to their roles in the nervous system. Prerequisite(s): A BIO 425, 312 or 341.

A BIO 442 Restoration Ecology (3) 
Restoration ecology seeks to enhance natural recovery of damaged ecosystems. Through lectures and readings, we review the science and practice of ecological restoration, with emphasis on application of ecological principles. Prerequisite(s): 15 credits in biology, including a course in organismal biology or ecology. May not be offered in 2009-2010.

A BIO 443 Restoration Ecology Laboratory (1)  
Demonstrations and laboratory exercises will explore tools for the design, implementation, and assessment of restoration projects in a variety of habitats. As the principal assignment, student teams will prepare a design plan for a restoration project. Prerequisite(s) or corequisite(s): A BIO 442, or permission of instructor. May not be offered in 2009-2010.

A BIO 455 Plant Ecology (3)
Current research and theoretical background in the field of plant ecology will be explored. Topics will include population and community dynamics, evolution of life history traits, physiological responses to environmental stresses, plant-animal interactions, and the role of vegetation in ecosystem processes. Prerequisite(s): A BIO 319, or A BIO 320, or permission of instructor. May not be offered in 2009-2010.

A BIO 456 Plant Ecology Laboratory (1)
Field and laboratory studies will explore experimental and analytical technique used in plant ecology. Topics include population dynamics, community patterns, plant-animal interactions, and vegetation mapping. Prerequisite(s) or corequisite(s): A BIO 455. May not be offered in 2009-2010.

A BIO 490 (= A PSY 490) Topics in Neuroscience (3)
This course is designed as the capstone course for the interdisciplinary Neuroscience Minor. It is expected that Minors will take this course in the fall of their senior year. This course will be team taught by Neuroscience faculty from Biology and Psychology and will cover current topics in neuroscience research, engaging students in the original research literature and providing information about graduate education and careers in neuroscience. Prerequisite(s): permission of instructor.

A BIO 499/499Z Supervised Research for Seniors (2-4)
Individual, independent research on selected topics in biology. Critical analysis of selected research papers. Senior majors in the department of biological sciences apply for this course through the prospective research adviser. A copy of the final written report of each semester’s work, preferably typewritten in journal format, is kept on permanent file in the department. May be taken either semester. Students taking two or more semesters of A BIO 399, 399Z, 499, or 499Z will prepare a poster or make an oral presentation at the Departmental Research Symposium. A maximum of 8 credits may be earned in A BIO 499 and 499Z.