Lauren Endres

The broad goal of my research program is to understand translational defense mechanisms that protect against oxidative-stress, with implications for the prevention of cancer and its progression from a benign to a malignant state. Specifically, I am investigating tRNA methyltransferases that are reactive oxygen species responsive and that show deregulated expression in a number of cancers, including colon, bladder, breast and ovarian. I aim understand the interrelationships between these fascinating enzymes, the modifications they catalyze, and known oncogenic and tumor suppressor signaling pathways.