Akamatsu, M., Yamashita, T., Teramoto, S., Huang, Z., Lynch, J., Toda, T., Niu, L., & Kwak, S. (2022) Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model. Life Science Alliance, 5(4).
Link to articleHuang, Z., & Niu, L. (2021) RNA aptamers for AMPA receptors. Neuropharmacology, 199, 108761.
Link to articleJaremko, W., Huang, Z., Karl, N., Pierce, V. D., Lynch, J., & Niu, L. (2020) A kainate receptor–selective RNA aptamer. Journal of Biological Chemistry, 295(19), 6280–6288.
Link to articleHuang, Z., & Niu, L. (2019) Developing RNA aptamers for potential treatment of neurological diseases. Future Medicinal Chemistry, 11(6), 551–565.
Link to articleJaremko, W. J., Huang, Z., Wen, W., Wu, A., Karl, N., and Niu, L. (2017) Identification and characterization of RNA aptamers: A long aptamer blocks the AMPA receptor and a short aptamer blocks both AMPA and kainate receptors. J Biol Chem 292, 7338-7347.
Link to articleHuang, Z., Kangovi, G. N., Wen, W., Lee, S., and Niu, L. (2017) An RNA Aptamer Capable of Forming Hydrogel by Self-Assembly. Biomacromolecules. 18, 2056-2063.
Link to articleHan, Y., Lin, C. Y., and Niu, L. (2017)Functional Roles of the Edited Isoform of GluA2 in GluA2-Containing AMPA Receptor Channels. Biomacromolecules. 18, 2056-2063.
Link to articleEspahbodinia, M., Ettari, R., Wen, W., Wu, A., Shen, Y. C., Niu, L., Grasso, S., and Zappala, M. (2017) Development of novel N-3-bromoisoxazolin-5-yl substituted 2,3-benzodiazepines as noncompetitive AMPAR antagonists. Bioorg Med Chem 25, 3631-3637.
Link to articleWang, C., Wu, A., Shen, Y. C., Ettari, R., Grasso, S., and Niu, L. (2015) Mechanism and site of inhibition of AMPA receptors: substitution of one and two methyl groups at the 4-aminophenyl ring of 2,3-benzodiazepine and implications in the "E" site. ACS Chem Neurosci 6, 1371-1378.
Link to articleLin, C. Y., Huang, Z., Wen, W., Wu, A., Wang, C., and Niu, L. (2015) Enhancing Protein Expression in HEK-293 Cells by Lowering Culture Temperature. PloS one 10, e0123562.
Link to articleHuang, Z., Lin, C. Y., Jaremko, W., and Niu, L. (2015) HPLC purification of RNA aptamers up to 59 nucleotides with single-nucleotide resolution. Methods in molecular biology (Clifton, N.J.) 1297, 83-93.
Link to articleWu, A., Wang, C., and Niu, L. (2014) Mechanism of inhibition of the GluA1 AMPA receptor channel opening by the 2,3-benzodiazepine compound GYKI 52466 and a N-methyl-carbamoyl derivative. Biochemistry 53, 3033-3041.
Link to articleWang, C., Han, Y., Wu, A., Solyom, S., and Niu, L. (2014) Mechanism and site of inhibition of AMPA receptors: pairing a thiadiazole with a 2,3-benzodiazepine scaffold. ACS Chem Neurosci 5, 138-147.
Link to articleWang, C., and Niu, L. (2013) Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives. ACS Chem Neurosci 4, 635-644.
Link to articleHuang, Z., Jayaseelan, S., Hebert, J., Seo, H., and Niu, L. (2013) Single-nucleotide resolution of RNAs up to 59 nucleotides by high-performance liquid chromatography. Analytical biochemistry 435, 35-43.
Link to articleHan, Y., Wang, C., Park, J. S., and Niu, L. (2012) Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant. Biochemistry 51, 761-768.
Link to articleWang, Z., Zhang, J., Chen, P., Zhou, X., Yang, Y., Wu, S., Niu, L., Han, Y., Wang, L., Chen, P., Boey, F., Zhang, Q., Liedberg, B., and Zhang, H. (2011) Label-free, electrochemical detection of methicillin-resistant Staphylococcus aureus DNA with reduced graphene oxide-modified electrodes. Biosens Bioelectron 26, 3881-3886.
Link to articleWang, C., Sheng, Z., and Niu, L. (2011) Mechanism of inhibition of the GluA2 AMPA receptor channel opening: consequences of adding an N-3 methylcarbamoyl group to the diazepine ring of 2,3-benzodiazepine derivatives. Biochemistry 50, 7284-7293.
Link to articleRitz, M., Wang, C., Micale, N., Ettari, R., and Niu, L. (2011) Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: the Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives. ACS Chem Neurosci 2, 506-513.
Link to articlePark, J. S., Wang, C., Han, Y., Huang, Z., and Niu, L. (2011) Potent and selective inhibition of a single alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit by an RNA aptamer. J Biol Chem 286, 15608-15617.
Link to articleHuang, Z., Han, Y., Wang, C., and Niu, L. (2010) Potent and selective inhibition of the open-channel conformation of AMPA receptors by an RNA aptamer. Biochemistry 49, 5790-5798.
Link to articlePei, W., Huang, Z., Wang, C., Han, Y., Park, J. S., and Niu, L. (2009) Flip and flop: a molecular determinant for AMPA receptor channel opening. Biochemistry 48, 3767-3777.
Link to articleHuang, Z., Pei, W., Han, Y., Jayaseelan, S., Shekhtman, A., Shi, H., and Niu, L. (2009) One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. Nucleic acids research 37, 4022-4032.
Link to articlePei, W., Ritz, M., McCarthy, M., Huang, Z., and Niu, L. (2007) Receptor occupancy and channel-opening kinetics: a study of GLUR1 L497Y AMPA receptor. J Biol Chem 282, 22731-22736.
Link to articlePei, W., Huang, Z., and Niu, L. (2007) GluR3 flip and flop: differences in channel opening kinetics. Biochemistry 46, 2027-2036. J Biol Chem 282, 22731-22736.
Link to articleKornreich, B. G., Niu, L., Roberson, M. S., and Oswald, R. E. (2007) Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6. Neuroscience 146, 1158-1168.
Link to articleHuang, Z., Pei, W., Jayaseelan, S., Shi, H., and Niu, L. (2007) RNA aptamers selected against the GluR2 glutamate receptor channel. Biochemistry 46, 12648-12655.
Link to articleLi, G., Sheng, Z., Huang, Z., and Niu, L. (2005) Kinetic mechanism of channel opening of the GluRDflip AMPA receptor. Biochemistry 44, 5835-5841.
Link to articleHuang, Z., Li, G., Pei, W., Sosa, L. A., and Niu, L. (2005) Enhancing protein expression in single HEK 293 cells. Journal of neuroscience methods 142, 159-166.
Link to articleLi, G., and Niu, L. (2004) How fast does the GluR1Qflip channel open?. J Biol Chem 279, 3990-3997.
Link to articleLi, G., Pei, W., and Niu, L. (2003) Channel-opening kinetics of GluR2Q(flip) AMPA receptor: a laser-pulse photolysis study. Biochemistry 42, 12358-12366.
Link to articleLi, G., Oswald, R. E., and Niu, L. (2003) Channel-opening kinetics of GluR6 kainate receptor. Biochemistry 42, 12367-12375.
Link to articleNiu, L., Kim, J. M., and Khorana, H. G. (2002) Structure and function in rhodopsin: asymmetric reconstitution of rhodopsin in liposomes. Proc Natl Acad Sci U S A 99, 13409-13412.
Link to articleHess, G. P., Ulrich, H., Breitinger, H. G., Niu, L., Gameiro, A. M., Grewer, C., Srivastava, S., Ippolito, J. E., Lee, S. M., Jayaraman, V., and Coombs, S. E. (2000) Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801. Proc Natl Acad Sci U S A 97, 13895-13900.
Link to articleBruel, C., Cha, K., Niu, L., Reeves, P. J., and Khorana, H. G. (2000) Rhodopsin kinase: two mAbs binding near the carboxyl terminus cause time-dependent inactivation. Proc Natl Acad Sci U S A 97, 3010-3015.
Link to articleGee, K. R., Niu, L., Schaper, K., Jayaraman, V., and Hess, G. P. (1999) Synthesis and photochemistry of a photolabile precursor of N-methyl-D-aspartate (NMDA) that is photolyzed in the microsecond time region and is suitable for chemical kinetic investigations of the NMDA receptor. Biochemistry 38, 3140-3147.
Link to articleNiu, L., Wieboldt, R., Ramesh, D., Carpenter, B. K., and Hess, G. P. (1996) Synthesis and characterization of a caged receptor ligand suitable for chemical kinetic investigations of the glycine receptor in the 3-microseconds time domain. Biochemistry 35, 8136-8142.
Link to articleNiu, L., Vazquez, R. W., Nagel, G., Friedrich, T., Bamberg, E., Oswald, R. E., and Hess, G. P. (1996) Rapid chemical kinetic techniques for investigations of neurotransmitter receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 93, 12964-12968.
Link to articleNiu, L., Gee, K. R., Schaper, K., and Hess, G. P. (1996) Synthesis and photochemical properties of a kainate precursor and activation of kainate and AMPA receptor channels on a microsecond time scale. Biochemistry 35, 2030-2036.
Link to articleNiu, L., Abood, L. G., and Hess, G. P. (1995) Cocaine: mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique. Proc Natl Acad Sci U S A 92, 12008-12012.
Link to articleHess, G. P., Niu, L., and Wieboldt, R. (1995) Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods. Ann N Y Acad Sci 757, 23-39.
Link to articleWieboldt, R., Gee, K. R., Niu, L., Ramesh, D., Carpenter, B. K., and Hess, G. P. (1994) Photolabile precursors of glutamate: synthesis, photochemical properties, and activation of glutamate receptors on a microsecond time scale. Proc Natl Acad Sci U S A 91, 8752-8756.
Link to articleRamesh, D., Wieboldt, R., Niu, L., Carpenter, B. K., and Hess, G. P. (1993) Photolysis of a protecting group for the carboxyl function of neurotransmitters within 3 microseconds and with product quantum yield of 0.2. Proc Natl Acad Sci U S A 90, 11074-11078.
Link to articleNiu, L., and Hess, G. P. (1993) An acetylcholine receptor regulatory site in BC3H1 cells: characterized by laser-pulse photolysis in the microsecond-to-millisecond time region. Biochemistry 32, 3831-3835.
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